Delivery system for biologically active growth or morphogenetic

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Miscellaneous

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A61F 202

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active

054435315

ABSTRACT:
A method of preparing a delivery system for a biologically active growth and morphogenetic factor by using chromatographic techniques and which includes introducing such biologically active factor into a chromatography column of appropriate dimensions which contains a porous carrier comprising a solid adsorbent selected for its specific affinity for such biologically active factor. In one embodiment of the invention porous hydroxyapatite is used as the carrier for bone morphogenetic proteins (ie BMPs). The invention extends to a delivery system prepared according to the above method; to an apparatus for preparing the delivery system according to the method; and to use of the delivery system in a method for inducing the formation of new bone in primates.

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Y. Horisaka, et al; "Subperiosteal Implantation of Bone Morphogenetic Protein Adsorbed by Hydroxyapatite"; Jul. 1991; Clinical Opthopaedics and Related Research No. 268; pp. 303-311.
M. Urist, et al; "Purification of Bovine Bone Morphogenetic Protein by Hydroxyapatite Chromatography"; Proceedings of the National Academy of Sciences of the U.S. of A. vol. 81, Jan. 1984; pp. 371-375.
T. K. Sampath, et al; "Isolation of Osteogenin, an Extracellular Matrix-associated, Bone-inductive Protein, by Herparin Affinity Chromatography", Oct. 1987; Proc. Natl. Acad. Sci. USA, vol. 84, pp. 7109-9113.
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U.S. patent application Ser. No. 07/720,174 filed Jun. 27, 1991 to U. Ripamonti.

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