Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1997-07-23
1999-10-26
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
A61K 31715
Patent
active
059729104
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to a delivery system for delivering a volatile and/or water soluble antimethanogenic agent to an animal, a composition comprising the agent and methods of treatment of an animal.
BACKGROUND OF INVENTION
Microorganisms capable of generating methane are commonly found in the gut flora of animals including ruminants. The microorganisms which produce methane in ruminants result in the loss of energy available to the animal and are also believed to contribute significantly to greenhouse gases.
Specifically, it has been known for many years that suppression of methane production in ruminants can theoretically lead to increased production and much work has been undertaken to reduce methane biosynthesis and achieve production gains in domestic animals. This has been most successfully achieved by modifications to the diet of animals. Diet manipulation is only possible in a limited number of animal production systems and is generally only able to reduce and not completely suppress methane production. A number of approaches to methane suppression in animals are being explored, not only to increase animal production but also to reduce the level of methane in the environment because of its contribution to the "greenhouse" effect.
Bromochloromethane (BMC) and some other related substances are known to show antimethanogenic activity when administered into the rumen of cattle and sheep but they have physical properties which makes impractical their use as antimethanogens in livestock production systems, BCM for example is a volatile liquid, boiling point 69 C., which readily evaporates. Bromoethane sulphonate, another antimethanogen, is difficult to administer because it is water soluble.
While the antimethanogenic properties of BCM and other antimethanogens have been known for more than 25 years no one has identified a practical means of using them to suppress methane production in livestock and obtain production increases.
Thus there has been a long felt need in the animal production field to find a practical means of inhibiting methanogenesis in animals, in particular ruminants.
It may also be desirable to reduce methane production in other animals. Inhibition of methane production would reduce the environmental impact of animals. In the case of domestic animals that inhabit households, it may be desirable to reduce methane production to achieve more pleasant conditions.
Cyclodextrins are cyclic oligosaccharides which have been used in the pharmaceutical and food industries in the preparation of various formulations incorporating active ingredients.
SUMMARY OF THE INVENTION
It is an object of the present invention to overcome at least some of the difficulties of the prior art in delivering antimethanogenic agents to animals.
In work leading up to the present invention the inventors recognised the possibility that BMC and related antimethanogenic substances might form inclusion complexes with one or more cyclodextrins although these inclusion complexes had not been produced previously. It was also possible, but by no means certain, that these inclusion complexes might have properties which would enable them to be used as practical antimethanogens for suppressing methane production in animals.
The inventors have now demonstrated that inclusion complexes are formed with a number of antimethanogenic substances and show that these complexes have antimethanogenic properties and physical properties which made them suitable for administration of livestock by several available delivery processes. The BCM-.alpha.-cyclodextrin inclusion complex is shown for example to have properties particularly suitable for administration to livestock either as a feed additive or in a controlled release device, to suppress methane production and to give production benefits in cattle and sheep.
In its broadest form the present invention provides a delivery system for delivering a volatile and/or water soluble antimethanogenic agent to an animal, said system comprising a volatile and/or water soluble antimethan
REFERENCES:
Canadian Journal of Animal Science, vol. 51, No. 3 (1971), Wood A.S. and Johnson, E.D., "Action of Antimethanogenic Agents on Diurnal Patterns of Fermentation Activity, Long Chain Fatty Acids, and Protozoa Count in Cattle", pp. 783-792.
Australian Journal of Agricultural Research, vol. 29, No. 6, (1978), Lanigan, G.W., et al, "Antimethanogenic Drugs and Heliotropium europacum Poisoning in Penned Sheep", pp. 1281-1292.
Edgar John Alexander
May Christopher
Payne Alan Lindsay
Stewart Philip Laurence
Commonwealth Scientific and Industrial Research Organisation
Weddington Kevin E.
LandOfFree
Delivery system for antimethanogenic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Delivery system for antimethanogenic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Delivery system for antimethanogenic agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-764604