Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1993-12-14
1995-08-29
Phelan, D. Gabrielle
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424464, 424489, 424490, 424493, 424494, 424496, A61K 948
Patent
active
054458269
ABSTRACT:
A prolonged-release unit dosage formulation or pharmaceutical composition, preferably in tablet form, is described. The composition consists essentially of a gel-forming fiber, preferably hydrocolloid-coated, a biologically-absorbable drug or other active therapeutic agent which is also preferably hydrocolloid-coated, a mineral salt which releases a physiologically-acceptable gas upon ingestion, preferably carbon dioxide, e.g., a mineral carbonate or bicarbonate, and optionally an organic or phosphoric acid and a dextrose or like soluble sugar. The fiber-containing composition, when in the form of a tablet or other unit dosage form together with the drug or agent and the stated disintegrants, provides a unique, efficient and controllable prolonged-action drug-delivery system.
REFERENCES:
patent: 1891698 (1932-12-01), Tuvin
patent: 3082091 (1963-03-01), Smith
patent: 4756911 (1988-07-01), Drost
patent: 4824672 (1989-04-01), Day
patent: 4844905 (1989-07-01), Ichikawa
patent: 4929448 (1990-05-01), Ibsen
Pharmacognosy, Tyler, V. E. ed., 7th edition, 1976.
Cibus Pharmaceutical, Inc.
Phelan D. Gabrielle
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