Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1994-06-16
1996-09-10
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424646, 435178, 514 2, 514 21, 514 54, 514169, 514179, 536 551, A61K 4726, A61K 3156, A61K 31495, A61K 3170, A61K 39395, A61K 3326, A61K 3821
Patent
active
055543863
ABSTRACT:
This invention relates to a method of directing a therapeutic agent to selected cells, wherein a complex is formed between a polysaccharide capable of interacting with a cell receptor and a therapeutic agent. The resulting complex is administered to a subject, and permitted to be internalized into the selected cells through a process known as receptor mediated endocytosis (RME). The polysaccharide may be, for example, arabinogalactan, gum arabic, mannan or hydrolysis products thereof; the therapeutic agent may be, for example, an antiviral agent, a nucleic acid, hormone, steroid, antibody, chemoprotective or radioprotective agent. The cell receptor may be for example, the asialoglycoprotein receptor or the mannose receptor.
REFERENCES:
patent: 2649421 (1953-08-01), Stacey et al.
patent: 2765244 (1956-10-01), Stacey et al.
patent: 4320194 (1982-03-01), Bull
patent: 4501726 (1985-02-01), Schroder et al.
patent: 4609640 (1986-09-01), Morishita et al.
patent: 4735796 (1988-05-01), Gordon
patent: 4770183 (1988-09-01), Groman et al.
patent: 4794170 (1988-12-01), Fiume et al.
patent: 4804529 (1989-02-01), Bardy et al.
patent: 4822594 (1989-04-01), Gibby
patent: 4827945 (1989-05-01), Groman et al.
patent: 4859449 (1989-08-01), Mattes
patent: 4861597 (1989-08-01), Kida et al.
patent: 4946675 (1990-08-01), Baldwin
patent: 4946830 (1990-08-01), Pulverer
patent: 5032678 (1991-07-01), Washino
patent: 5041541 (1991-08-01), Mazur
patent: 5129877 (1992-07-01), Gallo
patent: 5284646 (1994-02-01), Menz et al.
patent: 5336506 (1994-08-01), Josephson
1958 Bouveng, Acta Chemica Scandinavica 12:1977-1984.
1960 Whistler, Advances in Carbohydrate Chemistry 13:289-329.
1967 Albersheem et al., Carbohydrate Research 5:340-345.
1971 Nedelcheva et al., La Chimica e L'Industria 53:1018-1021.
1973 Richards et al., Carbohydrate Research 27:185-191.
1977 Young et al., Carbohydrate Research 59:193-201.
1983 Fincher et al., Ann. Rev. Plant Physiol. 34:47-70.
1983 Lai et al., J. App. Polymer Sci: Applied Polymer Symposium 37:943-953.
1983 Wu et al., Proc. Nat'l. Acad. Sci. 80:3078-3080.
1985 Vera et al, J. Nucl. Med. 26:1157-1167.
1985 Wu et al., Hepatology 5:709-713.
1987 Fiume et al., Cancer Drug Delivery 4:145-150.
1987 O'Mullane et al., "Biopharmaceutics of Microparticulate Drug Carriers," Ann. N.Y. Acad. Sci. 507:120-140.
1988 Strye, Biochemistry, 3d ed., NY:W. N. Freeman Co., pp. 343-344.
1988 Kanke et al., J. Parenteral Science and Technology 42:157-165.
1988 Fiume et al., Lancet 2:13-15.
1989 Kiyohara et al., Carbohydrate Research 187:117-129.
1989 Duvallet et al., Polymer Bulletin 21:517.
1989 Meijer, Pharm. Res. 6(2):105-118.
1990 Molema et al., Biochem. Pharm. 40:2603-2610.
1990 Al-Deen et al., J. Chromatography 512:409-414.
1990 Meijer, Trends in Drug Research, vol. 13, pp. 303-332.
1990 Roche et al., Res. Virol. 141:243-249.
1991 Dickinson et al. in "Food Polymers, Gels and Colloids," Special Publication No. 82, Proceedings of an international symposium by the Food Chemistry Group of the Royal Society of Chemistry, Dickinson, ed., Norwich England.
1991 Schein, International Conference on Chemical Modifiers of Cancer Treatment, Clearwater FL, pp. 341-342.
1992 Meijer, Antiviral Research, 18:215-258.
Arabinogalactan for Hepatic Drug Delivery, Groman, et al., Bioconjugate Chemistry, vol. 5, No. 6, 1994, pp. 547-556.
Conjugation of Adenine Arabinoside 5'-Monophosphate to Arabinogalactan: Synthesis, Characterization, and Antiviral Activity, Enriquez, et al., Bioconjugate Chemistry, vol. 6, No. 2, 1995, pp. 195-202.
Abullah and Kierszenbaum (1989), J. Cell Biol. 108, pp. 367-375.
Blake, Clarke, and Jansson (1983), Carbohydr Res 115, pp. 265-272.
Bodmer and Dean (1985) Methods in Enzymology 112, pp. 298-306.
Brown et al., (1978) Arch. Bioch. Biophys. 188, pp. 418-428.
Chibata (1978), Immobilized Enzymes, Halstead Press, New York.
Clarke, Anderson, and Stone (1979), Phytochemistry 18, pp. 521-540y.
Degols, et al. (1989), Nucleic Acids Res 17, pp. 9341-9350.
Dragsten et al. (1987) Biochem. Biophys. Acta 926, pp. 270-279.
Fallon and Schwartz (1985) Hepatology 5, pp. 899-901.
Furuno, et al. (1983), J. Biochem 93, p. 249.
Glicksman, ed. (1982) "Food Hydrocolloids" CRC Press, p. 5 and p. 33.
Gorin and Barreto-Bergter in "The Polysaccharides," vol. 2, G. O. Aspinall, ed., Academic Press, 1983, pp. 376-380.
Hamstra et al. (1980) JAMA 243, pp. 1726-1731.
Hartford and Ashwell in "The Glycoconjugates," vol. IV, M. I. Horowitz, ed., Academic Press, 1982, pp. 27-55.
Henderson and Hillman (1969) Blood 34, pp. 357-375.
Hill, et al. (1987), Pigment Cell Res 1, pp. 81-86.
Hofnagel (1986), J. Hepatol. 3, pp. S73-S80.
Hubbard, et al. (1979), J. Cell Biol. 83, pp. 47-64.
Josephson, et al. (1990), Mag. Res. Imag. 8, pp. 637-646.
Kligerman, et al. (1991), 7th International Conference on Chemical Modifiers of Cancer Treatment, Clearwater, FL, pp. 338-340.
Lee et al. (1984) Biochemistry 23, pp. 4255-4261.
Lee, Haekyung, Kelm, Sorge, Teruo, Yoshino, and Schauer (1988), Roland Biol. Chem., Hoppe-Seyler 369, pp. 705-714.
Lok, et al. (1984), J. Antimicrob. Chemother. 14, pp. 93-99.
Martin, C. R. (1976) "Textbook of Endocrine Physiology," Williams & Wilkins, p. 21.
Meizer and van der Sluijs (1989), Pharm. Res. 6, pp. 105-118.
Mukhopadhyay et al. (1989) Science 244, pp. 705-707.
Piper, et al. (1969), J. Med. Chem. 12, pp. 236-243.
Ranade, V. V. (1989), J. Clin. Pharmacol. 29, pp. 685-694.
Roitt (1991), Essential Immunology, Blackwell Scientific, London, p. 28.
Samoloski and Daynes (1985), Proc. Nat. Acad. Sci. 82, pp. 2508-2512.
Schein (1991), International Conference on Chemical Modifiers of Cancer Treatment, Clearwater, FL, pp. 341-342.
Schor, et al. (1990), Biochem J. 267, pp. 291-296.
Stockert and Becker (1980) Cancer Res. 40, pp. 3632-3634.
The Pink Sheet, Feb. 3, 1992, 54, #5.
van der Sluijs, et al. (1991), Liver Diseases, Targeted Diagnosis and Therapy Using Specific Receptors and Ligands, Marcel Dekker Inc., pp. 235-264.
Wileman et al. (1985) Biochem. J. 232, pp. 1-14.
Wong (1991), Chemistry of Protein Conjugation and Cross-Linking, CRC Press, Boca Raton.
Wu, et al. (1987), J. Biol Chem. 262, pp. 4429-2232.
Wu, et al. (1991), Hepatology 13, pp. 575-580.
Wu and Wu (1988) J. Biol. Chem. 263, pp. 14621-14624.
Enriquez Philip M.
Groman Ernest V.
Josephson Lee
Jung Chu
Lewis Jerome M.
Advanced Magnetics Inc.
Kishore Gollamudi S.
LandOfFree
Delivery of therapeutic agents to receptors using polysaccharide does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Delivery of therapeutic agents to receptors using polysaccharide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Delivery of therapeutic agents to receptors using polysaccharide will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1318849