Delivery of superoxide dismutase to neuronal cells

Details Delivery of superoxide dismutase to neuronal cells Delivery of superoxide dismutase to neuronal cells

2005-02-22

2008-12-30

Kemmerer, Elizabeth C. (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S006900, C424S094100, C530S350000, C530S402000, C435S183000

Reexamination Certificate

active

07470661

ABSTRACT:
A composition for delivery of superoxide dismutase to neuronal cells comprise a superoxide dismutase linked by a linker to a neuronal cell targeting component, which component comprises a first domain that binds to a neuronal cell and a second domain that translocates the superoxide dimutase into the neuronal cell. After translocation, the linker is cleaved to release superoxide dimutase from the neuronal cell targeting domain. Also described is use of the composition for treatment of oxidative damage to neuronal cells and further targeting of the composition using human mitochondrial leader sequences. A hybrid polypeptide is described that contains a bacterial superoxide dismutase plus a sequence that targets a human mitochondira.

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