Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1998-03-06
1999-10-12
Railey, II, Johnny F.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 691, 435 693, 4352521, 4352523, 4353201, 435373, 435480, 424 932, C12N 121, C12N 1574, C12Q 102, C07K 1424
Patent
active
059653817
ABSTRACT:
The present invention relates to recombinant Yersinia and the use thereof for delivery of proteins into eukaryotic cells, including related compositions and methods of treatment and related assays.
REFERENCES:
patent: 5342774 (1994-08-01), Boon et al.
patent: 5405940 (1995-04-01), Boon et al.
patent: 5530096 (1996-06-01), Wolfel et al.
Michiels et al., J. Bacteriology 173(16):4994-5009 (1991).
G.R. Cornelis and H. Wolf-Watz (1997) "The Yersinia Yop Virulon: A Bacterial System for Subverting Eukaryotic Cells" Molecular Microbiology 23 (5): 861-867.
V.L. Miller and S. Falkow (1988) "Evidence for Two Genetic Loci in Yersinia Enterocolitica That Can Promote Invasion of Epithelial Cells" Infect. Immun. 56 (5): 1242-1248.
R. Rosqvist et al. (1991) "Intracellular Targeting of the Yersinia YopE Cytotoxin in Mammalian Cells Induces Actin Microfilament Disruption" Infect. Immun. 59 (2): 4562-4569.
E.L. Hartland et al. (1994) "Essential Role of YopD in Inhibition of the Respiratory Burst of Macrophages by Yersinia enterocolitica" Infect Immun. 62 (10): 4445-4453.
R. Rosqvist et al. (1988) "Inhibition of Phagocytosis in Yersinia pseudotuberculosis: A Virulence Plasmid-encoded Ability Involving the Yop2b Protein" Infect. Immun. 56 (8): 2139-2143.
J. Bliska and D.S. Black (1995) "Inhibition of the Fc Receptor-mediated Oxidative Burst in Macrophages by the Yersinia pseudotuberculosis Tyrosine Phosphatase" Infect. Immun. 63 (2): 681-685.
S. Hakansson et al. (1996) "The Yersinia YpkA Ser/Thr Kinase is Translocated and Subsequently Targeted to the Inner Surface of the HeLa Cell Plasma Membrane" Mol. Microbiol. 20 (3): 593-603.
K.Y. Leung and S.C. Straley (1989) "The yopM Gene of Yersinia pestis Encodes a Released Protein Having Homology With the Human Platelet Surface Protein GPIb" J. Bacterial. 171 (9): 4623-4632.
S.D. Mills et al. (1997) "Yersinia enterocolitica Induces Apoptosis in Macrophages . . . " Proc. Natl. Acad. Sci. USA 94: 12638-12643.
M. Sory et al. (1995) "Identification of the YopE and YopH Domains Required for Secretion . . . " Proc. Natl. Acad. Sci. USA 92: 11998-12002.
A. Boland et al. (1996) "Status of YopM and YopN in the Yersinia Yop Virulon . . . " The EMBO Journal 15 (19): 5191-5201.
J.B. Van den Eynde and P. van der Bruggen (1997) "T cell Defined Tumor Antigens" Current Opinion in Immunology 9: 684-693.
U. Sahin et al. (1997) "Serological Identification of Human Tumor Antigens" Current Opinion in Immunology 9: 709-716.
D.L. Shawler et al. (1997) "Gene Therapy Approaches to Enhance Antimumor Immunity" Advances in Pharmacology 40: 309-337.
K. Kaniga et al. (1991) "A Wide-host-range Suicide Vector for Improving Reverse Genetics in Gram-nega Bacteria: Inactivation of the bla4 gene of Yersinia enterocolitica" Gene 109: 137-141.
M.R. Sarker and G.R. Cornelis (1997) "Direct Repeat Sequences in the cagA Gene of Helicobacter pylori: A Ghost of a Chance Encounter?" Molecular Microbiology 23 (2): 409-411.
M.P. Sory and G.R. Cornelis (1994) "Translocation of a Hybrid YopE-adenylate Cyclase From Yersinia Enterocolitica into HeLa Cells" Molecular Microbiology 14(3): 583-594.
S.A. Thompson et al. (1995) "Minimal Epitopes Expressed in a Recombinant Polyepitope Protein . . . " Proc. Natl. Acad. Sci. USA 92: 5845-5849.
S.C. Gilbert et al. (1997) "A Protein Particle Vaccine Containing Multiple Malaria Epitopes" Nature Biotechnology 15: 1280-1284.
O. Tureci et al. (1997) "Serological Analysis of Human Tumor Antigens: Molecular Definition and Implications" Molecular Medicine Today 3 (8): 342-349.
Boland Anne M.
Boon-Falleur Thierry R.
Cornelis Guy R.
van der Bruggen Pierre B.
Ludwig Institute for Cancer Research
Railey II Johnny F.
Universite Catholique de Louvain
LandOfFree
Delivery of proteins into eukaryotic cells with recombinant yers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Delivery of proteins into eukaryotic cells with recombinant yers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Delivery of proteins into eukaryotic cells with recombinant yers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-651093