Delivery of polypeptide-encoding plasmid DNA into the cytosol of

Details Delivery of polypeptide-encoding plasmid DNA into the cytosol of Delivery of polypeptide-encoding plasmid DNA into the cytosol of

1997-12-29

2000-11-07

Crouch, Deborah

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 4242001, 424 932, 424 934, C12N 121, C12N 1563, A61K 3500

Patent

active

061435511

ABSTRACT:
The invention relates to the introduction of DNA or RNA sequences into a mammalian cell to achieve controlled expression of a polypeptide. It is therefore useful in gene therapy, vaccination, and any therapeutic situation in which a polypeptide should be administered to a host or cells of said host, as well as for the production of polypeptides by mammalian cells, e.g., in culture or in transgenic animals.

REFERENCES:
patent: 5763251 (1998-06-01), Gasson
Verma et al. (Sep. 1997) Nature, vol. 389, 239-242.
Bachmann et al. (1994) Current Opinion in Immunology, vol. 6, 320-326.

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