Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Patent
1997-08-19
1999-12-07
Degen, Nancy
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
435325, 435456, 536 231, C12N 700, C12N 1586, C12N 500, C07H 2104
Patent
active
05998192&
ABSTRACT:
The invention relates to a recombinant viral particle capable of delivering a nucleic acid to mammalian cells, the particle including a member of a first specific binding pair capable of binding to a first receptor expressed on the surface of a cell so as to cause infection thereof, and a surface-exposed member of a second specific binding pair capable of binding to a second receptor generally not expressed on the surface of the cell, such that binding of the viral particle to the second receptor via the member of the second specific binding pair inhibits infection of the cell by the viral particle.
Bullough Frances Joanne
Collins Mary Katharine Levinge
Cosset Francois-Loic
Russell Stephen James
Weiss Robin Anthony
Degen Nancy
Medical Research Council
Sandals William
Williams Kathleen M.
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