Delivery of nucleic acid to cells

Details Delivery of nucleic acid to cells Delivery of nucleic acid to cells

1996-06-03

1999-10-26

Stanton, Brian R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435375, 4353201, 424 932, 424 9321, 514 2, 536 231, 536 245, A61K 4800, C12N 1509, C12N 1563, C07H 2104

Patent

active

059729007

ABSTRACT:
Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.

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