Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1997-11-17
1999-09-28
Reeves, Julie
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
5303872, 5303873, 514 2, 514 44, 424 111, 424 141, 424 157, 424 165, 424 169, 424 173, 424 93, 424 934, 424 9341, 424 935, 424 9351, 424 936, 424 96, 4241781, 4241831, 424900, 4241333, A61K 39395, C12N 1511, C07M 2100, C07K 1600
Patent
active
059584084
ABSTRACT:
An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the targeting species, whereby non-bound primary targeting species is cleared from circulation but the clearing agent does not remove the bound primary targeting species. Anti-idiotype antibodies and antibody fragments are preferred clearing agents. Fast clearance is achieved by glycosylating the clearing agent with sugar residues that bind to the hepatic asialoglycoprotein receptor.
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Govindan Serengulam V.
Griffiths Gary L.
Hansen Hans J.
Karacay Habibe
Immunomedics Inc.
Reeves Julie
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