Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1996-10-09
1999-10-12
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
4241311, 424 111, 424 141, 424 149, 424 157, 424 165, 424 169, 424 173, 424 93, 424 934, 424 9341, 424 935, 424 9351, 424 936, 424 96, 4241781, 4241831, 424900, 514 2, 514 44, 435 75, 435 76, 435 79, A61K 39395, A61K 5100, A01N 3718, G01N 3353
Patent
active
059651318
ABSTRACT:
An improvement in in vivo pretargeting methods for delivering diagnostic or therapeutic agents to a target site in a mammal uses a clearing agent that binds to the target-binding site of the targeting species, whereby non-bound primary targeting species is cleared from circulation but the clearing agent does not remove the bound primary targeting species. Anti-idiotype antibodies and antibody fragments are preferred clearing agents. Fast clearance is achieved by glycosylating the clearing agent with sugar residues that bind to the hepatic asialoglycoprotein receptor.
REFERENCES:
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S. Hakomori et al., "Glycolipid Tumor Cell Markers and their Monoclonal Antibodies: Drug Targeting and Immunosuppression", pp. 177-199 (1983).
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Govindan Serengulam V.
Griffiths Gary L.
Hansen Hans J.
Karacay Habibe
Hutzell Paula K.
Immunomedics Inc.
Worrall Timothy A.
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