Delivery of compacted nucleic acid to cells

Details Delivery of compacted nucleic acid to cells Delivery of compacted nucleic acid to cells

1998-07-13

2000-06-20

Ketter, James

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435456, 435458, A61K 3170

Patent

active

060778350

ABSTRACT:
Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.

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