Delivery of aerosol medications for inspiration

Surgery – Liquid medicament atomizer or sprayer

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

12820023, 12820312, 12820523, A61M 1100

Patent

active

058265708

ABSTRACT:
Apparatus and methods for delivering an amount of aerosolized medicine for inspiration by a patient in response to the occurrence of appropriate delivery point or points in the patient's detected breath flow. The aerosol medication may be administered as one or more pulses having a pulse width, shape, and frequency that will maximize the respirable fraction of the aerosolized compound being administered. The delivery point or points may be predetermined or determined from a prior inspiratory flow for depositing the selected medication at one or more desired locations in the patient's airway. Determined delivery points are recursively lowered for each inspiratory flow that does not satisfy one of the predetermined and previously lowered threshold. Changes in the patient's breath flow patterns during the course of an aerosolized medication inspiration therapy program may be detected and used to adjust the controlled amount of medication to be delivered in a given administration and/or to inform the patient of the patient's condition or change in condition. The device also may contain a library of administration protocols or operating parameters for different medications and a means for identifying from the canister the medicinal contents of the canister for customizing operation of the apparatus.

REFERENCES:
patent: Re29117 (1977-01-01), Sahajian et al.
patent: 3157179 (1964-11-01), Paullus et al.
patent: 3187748 (1965-06-01), Mitchell et al.
patent: 3211346 (1965-10-01), Meshberg
patent: 3356088 (1967-12-01), Nelson
patent: 3394851 (1968-07-01), Gorman
patent: 3456644 (1969-07-01), Thiel
patent: 3456645 (1969-07-01), Brock
patent: 3456646 (1969-07-01), Phillips et al.
patent: 3464596 (1969-09-01), Meshberg
patent: 3565070 (1971-02-01), Hanson et al.
patent: 3636949 (1972-01-01), Kropp
patent: 3658059 (1972-04-01), Steil
patent: 3789843 (1974-02-01), Armstrong et al.
patent: 3812854 (1974-05-01), Michaels et al.
patent: 3814297 (1974-06-01), Warren
patent: 3826413 (1974-07-01), Warren
patent: 3830404 (1974-08-01), Frazer
patent: 3878973 (1975-04-01), Riccio
patent: 3940023 (1976-02-01), Umstead
patent: 3952916 (1976-04-01), Phillips
patent: 3968905 (1976-07-01), Pelton
patent: 3974941 (1976-08-01), Mettler
patent: 3991304 (1976-11-01), Hillsman
patent: 4106503 (1978-08-01), Rosenthal et al.
patent: 4117958 (1978-10-01), Spitzer et al.
patent: 4124149 (1978-11-01), Spitzer et al.
patent: 4256017 (1981-03-01), Eastman
patent: 4291688 (1981-09-01), Kistler
patent: 4361401 (1982-11-01), Smith, Jr. et al.
patent: 4366743 (1983-01-01), Leszczewski
patent: 4386553 (1983-06-01), Thoman et al.
patent: 4413755 (1983-11-01), Brunet
patent: 4427137 (1984-01-01), Dubini
patent: 4446862 (1984-05-01), Baum et al.
patent: 4462398 (1984-07-01), Durkan et al.
patent: 4469255 (1984-09-01), Hill et al.
patent: 4484577 (1984-11-01), Sackner et al.
patent: 4524769 (1985-06-01), Wetterlin
patent: 4534343 (1985-08-01), Nowacki et al.
patent: 4558710 (1985-12-01), Eichler
patent: 4576157 (1986-03-01), Raghuprasad
patent: 4592348 (1986-06-01), Waters, IV et al.
patent: 4604847 (1986-08-01), Moulding, Jr. et al.
patent: 4624251 (1986-11-01), Miller
patent: 4648393 (1987-03-01), Landis et al.
patent: 4662537 (1987-05-01), Wolf et al.
patent: 4664107 (1987-05-01), Wass
patent: 4677975 (1987-07-01), Edgar et al.
patent: 4679555 (1987-07-01), Sackner
patent: 4682713 (1987-07-01), Clapp
patent: 4693853 (1987-09-01), Falb et al.
patent: 4702400 (1987-10-01), Corbett
patent: 4745925 (1988-05-01), Dietz
patent: 4790305 (1988-12-01), Zoltan et al.
patent: 4803978 (1989-02-01), Johnson, IV et al.
patent: 4805609 (1989-02-01), Roberts et al.
patent: 4819629 (1989-04-01), Jonson
patent: 4832012 (1989-05-01), Raabe et al.
patent: 4852582 (1989-08-01), Pell
patent: 4860740 (1989-08-01), Kirk et al.
patent: 4896832 (1990-01-01), Howlett
patent: 4922901 (1990-05-01), Brooks et al.
patent: 4926852 (1990-05-01), Zoltan et al.
patent: 4932402 (1990-06-01), Snook et al.
patent: 4933873 (1990-06-01), Kaufman et al.
patent: 4934358 (1990-06-01), Nilsson et al.
patent: 4942544 (1990-07-01), McIntosh et al.
patent: 4984158 (1991-01-01), Hillsman
patent: 5069204 (1991-12-01), Smith et al.
patent: 5133343 (1992-07-01), Johnson, IV et al.
patent: 5293865 (1994-03-01), Altner et al.
patent: 5497764 (1996-03-01), Ritson et al.
Newman et al., "How Should A Pressurized Beta-Adrenergic Bronchodilator Be Inhaled?", Eur. J. Respir. Dis., 11981) vol. 62, pp. 3-21.
"Aerosol Drug Therapy for the Treatment of Obstructive Airway Disease," pp. 3-16, (Schering Laboratories, Kenilsworth, NJ).
Kohler, "Aerosols for Systemic Treatment", Lung, (1990) Suppl: 677-684.
3M HealthCare, Product Information, Jul. 1988, "Aerosol Non-sheathed Actuator and Cap".
Newman et al. "Deposition of Pressurized Aerosols in the Human Respiratory Tract" Thorax, 1981 vol. 36, 1981, vol. 35, p. 52.
Newman et al. "Deposition of Pressurized Suspension Aerosols Inhaled Through Extension Devices" Am Rev Respir Dis, 1981, vol. 124 pp. 317-320.
Moren "Drug Deposition of Pressurized Inhalation Aerosols: II. Influence of Vapor Pressure and Metered Volume", International Journal of Pharmaceuticals, 1 (1978) pp. 213-218.
Sullivan et al., "Pneumotachographs: Theory and Clinical Application" Respiratory Care, Jul. 1984, vol. 29, No. 7, pp. 736-749.
Bennett, "Targeting Aerosol Delivery in the Lung", Aerosol Age, Nov. 1990, pp. 32-35.
3M HealthCare, Product Information, Jul. 1988, "Aerosol System The Standard of Pharmaceutical Precision".
Byron, (ed)., Respiratory Drug Delivery, CRC Press, Inc. (1990) pp. 173-178.
Newmann, Deposition and Effects of Inhalation Aerosols, 1983 RAHMS; Lund Tryckeri AB.
McIlreath et al, "The Value of an Automatic Inhalation Device for Asthmatic Children", The Journal of Asthma Research, vol. 10, No. 1, Sep. 1972.
Cohen, "`Metered` Aerosols of Bronchodilator Drugs in Clinical Trials", Thorax (1971), vol. 2 pp. 316-318.
Spector et al., "Compliance of Patients with Asthma with an Experimental Aerosolized Medication: Implications for Controlled Clinical Trials" J. Allergy Clin. Immunol. (1986) vol. 77, pp. 65-70.
Gong, Jr. et al., "Metered-dose Inhaler Usage in Subjects with Asthma: Comparison of Nebulizer Chronolog and Daily Diary Recordings" J. Allergy Clin. Immunol. (1988) vol. 82, pp. 5-10.
Cohen, "Color Presentation of Breath Sounds", Respiration, vol. 29, pp. 234-246 (1972).
Heyder "Charting Human Thoracic Airways by Aerosols", Clin. Phys. Physio. Meas., 1983, vol. 4, No. 1, pp. 29-37.
Ryan et al. "Standardization of Inhalation Provocation Tests: Two Techniques of Aerosol Generation and Inhalation Compared" Am. Rev. Respir. Dis., (1981), vol. 123, pp. 195-199.
Chai et al., "Standardization of Bronchial Inhalation Challenge Procedures" J. Allergy Clin. Immunol., vol. 56, No. 4, pp. 323-327 Oct. 1975.
Rosenthal et al. "Role of the Parasympathetic System in Antigen-Induced Bronchospasm" J. Appl. Physiol.: Respirat. Environ. Exercise Phisiol., 42(4) pp. 600-606, 1977.
Nieminen et al. "Aerosol Deposition in Automatic Dosimeter Nebulization" Eur. J. Respir. Dis., (1987) 71, pp. 145-152.
Lee et al. "Aerosol Inhalation Teaching Device" J. Pediatrics., 1987, vol. 110, pp. 249-252.
Newman, Stephen P., "Inhalation Apparatus", Deposition and Effects of Inhalation Aerosols, Chapter 2, pp. 23-30 (Lund, Sweden 1983).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Delivery of aerosol medications for inspiration does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Delivery of aerosol medications for inspiration, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Delivery of aerosol medications for inspiration will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1606499

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.