Surgery – Controlled release therapeutic device or system – Implanted dynamic device or system
Reexamination Certificate
2007-06-19
2007-06-19
Sirmons, Kevin C. (Department: 3767)
Surgery
Controlled release therapeutic device or system
Implanted dynamic device or system
C604S890100, C604S066000, C604S500000, C604S503000, C604S508000
Reexamination Certificate
active
10773965
ABSTRACT:
A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms and otherwise treat heart failure (HF) and pathologies associated with HF. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with HF (or pathologies associated with HF) and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist, e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine.
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Hildebrand Keith R.
Page Linda M.
Sigg Daniel C.
Ujhelyi Michael R.
Zhou Xiaohong
McDowall Paul H.
Medtronic Inc.
Sirmons Kevin C.
Witczak Catherine N.
Wolde-Michael Girma
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