Delivery formulation for probucol

Details Delivery formulation for probucol Delivery formulation for probucol

1994-06-22

1996-02-27

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Sulfur, selenium or tellurium compound

A61K 3110

Patent

active

054949360

ABSTRACT:
A lipophilic pharmaceutical formulation including a digestible vegetable oil and a phenolic antioxidant such as probucol is disclosed for oral administration. The probucol will typically be present in an amount of between 5 and about 15% by weight and the digestible vegetable oil will be present in an amount of between about 80 and 95% by weight. A small quantity of ethanol may be added to the formulation to increase the solubility of probucol. The formulations will be orally administered for treatment of hypercholesterolemic patients and others suffering from certain ailments.

REFERENCES:
patent: 4985465 (1991-01-01), Hendler
Hegg et al., J. of Pharm. Sci., 73(12), pp. 1758-1763 (1984).
Palin et al., J. Pharmacy & Pharacology, 35, p. 85p (1983).

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