Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1985-07-22
1987-07-21
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
514965, 424487, A61K 922, A61K 932
Patent
active
046817557
ABSTRACT:
A delivery device for zero-order release of an active principle into a dissolution fluid includes a reservoir consisting of a solid matrix of a homogeneous mixture of a polymer material, at least a portion of the active principle and an additive soluble in the dissolution fluid with negative heat of solution, a coating on the solid matrix-type reservoir of a first, release rate-controlling insoluble membrane which modulates the active principle release according to the desired kinetics; and a second, protective membrane on the release rate-controlling membrane of a soluble polymer material.
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Colombo Paolo
Conte Ubaldo
Reiner Alberto
Collins Bruce M.
Griffin Ronald W.
Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
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