Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1996-10-31
1998-09-29
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435 6, 4353201, 536 241, 536 245, C12Q 102
Patent
active
058145001
ABSTRACT:
A novel nucleic acid construct for delivery of antisense targeting sequences is provided. The construct includes intact stem loop structures and an antisense nucleic acid. Optionally, a ribozyme nucleic acid is included in the construct. The construct is useful for inhibition of selected genes in a cell. This allele-specific targeting is also useful in combination with replacement gene therapy.
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Baserga and Steitz, (1993), "The Diverse World of Small Ribonucleoproteins," The RNA World, Cold Spring Harbor Laboratory Press, New York, pp. 359-381.
Chambers Jasemine C.
Clark Deborah J. R.
The Johns Hopkins University School of Medicine
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