Measuring and testing – Sampler – sample handling – etc. – Capture device
Reexamination Certificate
2000-10-18
2002-08-13
Williams, Hezron (Department: 2856)
Measuring and testing
Sampler, sample handling, etc.
Capture device
C073S864110, C073S864140, C422S105000
Reexamination Certificate
active
06431015
ABSTRACT:
FIELD OF THE INVENTION
The invention relates to an interchangeable pipette tip and a method for its production, a delivery apparatus for use with such pipette tips and a pipetting system. Such parts and devices are used in particular in chemical, biological and medical laboratories for pipetting liquids.
PRIOR ART
The Genesis system from TECAN AG comprises a pipetting system which can be operated with interchangeable plastics pipette tips of the generic type, in which the inlet orifice at the rear end is open. Every pipette tip is connected to a diluter by means of a tube which can be led through a solenoid valve. The delivery of a small amount of liquid from the air is then triggered in each case by operating the solenoid valve. The system permits the delivery of liquid amounts between 1 &mgr;l and 10 &mgr;l with generally sufficient accuracy.
If, however, even smaller amounts of liquid—between 1 nl and 1 &mgr;l—are to be delivered with high accuracy, the system described does not meet the requirements in every case.
SUMMARY OF THE INVENTION
It is the object of the invention to provide an interchangeable pipette tip, a delivery apparatus for use with such pipette tips and a pipetting system, which permit the delivery of very small amounts of liquid—in particular in the range from 1 nl to 1 &mgr;l—with high accuracy. In addition, it is intended to provide a suitable method for the production of an interchangeable pipette tip. This object is achieved by the invention as characterized in the Claims.
The advantages achieved by the invention are in particular that even very small volumes of liquid can be delivered with high accuracy. Moreover, carry-over of sample liquid between successive pipetting operations and its possible consequences, such as falsification of results or clogging of lines by agglomeration, are kept at an extremely low level, since the pipette tips can in each case be changed in between and direct contact of other parts of the delivery apparatus with the sample liquid can be avoided. The pipette tips can be produced very economically so that frequent changing thereof is scarcely an important factor with regard to the costs. The delivery apparatus, too, is relatively cheap to produce.
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patent: 4444062 (1984-04-01), Bennet et al.
patent: 5343909 (1994-09-01), Goodman
patent: 5763278 (1998-06-01), Sickinger et al.
patent: 6045757 (2000-04-01), Moriarty et al.
patent: 6098802 (2000-08-01), Asa et al.
patent: 0 187 167 (1986-07-01), None
patent: WO 90/14162 (1990-11-01), None
patent: WO 95/00392 (1995-01-01), None
Benedetti Mario
Fornito Stefano
Hälg Werner
Hodac Agathe
Ingenhoven Nikolaus
Garber C D
Notaro $ Michalos PC
Tecan Trading AG
Williams Hezron
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