Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-03-17
1997-10-28
Degen, Nancy
Chemistry: molecular biology and microbiology
Vector, per se
435 691, 536 241, C12N 1585, C12N 1563, C07H 2104, C12P 2102
Patent
active
056817444
ABSTRACT:
DNA vectors containing an effective upstream enhancer region of a tissue or organ specific mammalian promoter of an endogenous gene and a selected gene useful in delivery of the selected gene to a tissue or organ of an animal are provided. A method for evaluating the efficacy of agents in facilitating transfection is also provided.
REFERENCES:
patent: 5476926 (1995-12-01), Spiegelman et al.
patent: 5486462 (1996-01-01), Rutter et al.
Devine-Beach et al., Analysis of the proximal transcriptional element of the myelin basic protein gene, Nucleic Acids Res. 20(3):545-550 Feb. 11, 1992.
Agnati et al., "Evidence for Cholecystokinin-Dopamine Receptor Interactions in the Central Nervous System of the Adult and Old Rat," (1985) Ann. NY Acad. Sci..
Bancroft et al., "Control of the Production of Two Protein Hormones by Rat Pituitary Cells in Culture," (1970) In Vitro 6:180-189.
Beato et al., "DNA Regulatory Elements for Steroid Hormones," (1989) J. Steroid Biochem. 32:737-747.
Cato et al., "Different Regions of hte Estrogen Receptor are Required for Synergisic Action with the Glucocorticoid and Progesterone Receptors," (1989) Mol. Cell Biol. 9:5324-5330.
Dahlman-Wright et al., "DNA-Binding by the Glucocorticoid Receptor: A Structural and Functional Analysis," (1992) J. Steroid Biochem. Mol. Biol. 41:249-272.
Danesch et al., "Glucocorticoid Induction of the Rat Tryptophan Oxygenase Gene is Medicated by Two Widely Separated Glucocorticoid-Responsive Elements," (1987) EMBO J. 6:625-630.
Deschenes et al., "Cloning and Sequence Analysis of a cDNA Encoding Rat Preprocholecystokinin," (1984) Proc. Nat'l Acad. Sci. USA 81:726-730.
Dockray, G.J., "Immunochemical Evidence of Cholecystokinin-like Peptides in Brain," (1976) Nature 264:568-570.
Friedman et al., "Differential Expression of hte Mouse Cholecystokinin Gene During Brain and Gut Development," (1985) Proc. Nat'l Acad. Sci. USA 82:5593-5597.
Greenstein, R.J., "The Brain-Gut Axis: A Model System to Study Gene Regulation," (1992) Mt. Sinai J. Med. 59:135-138.
Greenstein et al., "Is Aging Preprogrammed? Observations from the Brain/Gut Axis," (1991) Mech. Aging Dev. 61:113-121.
Greenstein et al., "Cholecystokinin Upregulation during Intestinal Repair," (1992) J. Surg. Res. 53:12-16.
Haun et al., "Transcriptional Enhancer Essential for the Expression of the Rat Cholecystokinin Gene Contians a Sequence Identical to the -296 Development of the Human c-fos Gene," (1990) J. Biol. Chem. 265:15455-15463.
Ichihara et al., "Ontogeny of Immunoreactive CCk, VIP and Secretin in Rat Brain and Gut," (1983) Biochem. Biophys. Res. Comm. 112:891-898.
Konings et al., "Processing, Release and Metabolism of Cholecystokinin in SK-N-MCIXC Cells," (1993) Neuropeptides 25:19-30.
Moore et al., "The First Intron of the Human Growth Hormone Gene Contains a Binding Site for Glucocorticoid Receptor," (1985) Proc. Natl. Acad. Sci. USA 82:699-702.
Monstein, H.J., "Identification of an AP-1 Transcription Factor Binding Site within the Human Cholecystokinin (CCK) Promoter," (1993a) Neuroreport. 4:195-197.
Monstein, H.J., "Modulated Cholecystokinin (CCK) mRNA Expression is Dependent on de novo Protein Synthesis," (1993b) Neuroreport. 4:1167-1170.
Muller et al., "Cholecystokinin and its COOH-Terminal Octapeptide in the Pig Brain," (1977) Proc. Nat'l Acad. Sci. USA 74:3035-3037.
Oro et al., "Estrous Cycle Variations in Levels of Cholecystokinin Immunoreactivity within Cells of Three Interconnected Sexually Dimorphic Forebrain Nuclei," (1988) Neuroendocrinology 47:225-235.
Slater et al., "Glucocortincoid Receptor Binding and Activation of a Heterologo Promoter by Dexamethasone by the First Intron of the Human Growth Hormone Gene," (1985) Mol. Cell. Biol. 5:2984-2992.
Simerly et al., "Castration Reversable Alters Levels of Chlecystokinin Immunoreactivity within Cells of Three Interconnected Sexually Dimorphic Forebrain Nuclei in the Rat," (1987) Proc. Nat'l Acad. Sci. USA 84:2087-2091.
Tashjian et al., "Establishment of Clonal Strains of Rat Pituitary Tumor Cells the Secrete Growth Hormone," (1968) Endocrinology 82:342-352.
Truss et al., "Functional Interaction of Hybrid Response Elements with Wild-Type and Mutant Steroid Hormone Receptors," (1991) Mol. Cell Biol. 11:3247-3258.
Vanderhaegen et al., "New Peptide in the Vertebrate CNS Reacting with Antigastrin Antibodies," (1975) Nature 257:604-605.
Zhang et al., "Positional Cloning of the Mouse obese Gene and its Human Homologue," (1995) Nature 372:425-432.
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