Delivery and activation through liposome incorporation of diamin

Details Delivery and activation through liposome incorporation of diamin Delivery and activation through liposome incorporation of diamin

1996-12-06

1998-12-01

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 9127

Patent

active

058434755

ABSTRACT:
Antitumor compositions are disclosed, as well as methods of preparing the compositions and methods of using them to inhibit tumor growth in mammals. The invention can take advantage of intraliposomal conversion of a platinum complex having the formula ##STR1## where R.sub.1 is diaminocycloalkyl, and R.sub.2 and R.sub.3 each have the formula ##STR2## where R.sub.4, R.sub.5, and R.sub.6 are each independently hydrocarbon moieties having from 1 to about 10 carbon atoms,

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