Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2001-04-03
2008-11-25
Kishore, Gollamudi (Department: 1612)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S428000, C514S078000
Reexamination Certificate
active
07455855
ABSTRACT:
An object of the present invention is to prepare substances which are excellent in delivery and enable drugs to be retained in a body effectively over a long period and to construct a drug delivery system using the substances. When the delivering substance which is obtained by reacting polyalkylene glycol or a reactive derivative thereof, a phospholipid and a drug with each other to form covalent bonds is administered systemically or topically, the substance is retained at a target site in a body for a long period, thereby making it possible to sustain drug efficacy over a long period by a single administration.
REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4804539 (1989-02-01), Guo et al.
patent: 5308624 (1994-05-01), Maincent et al.
patent: 5411947 (1995-05-01), Hostetler et al.
patent: 6060463 (2000-05-01), Freeman
patent: 6171614 (2001-01-01), Chaikof et al.
patent: 6204054 (2001-03-01), Sutton et al.
patent: 6258351 (2001-07-01), Harris
patent: 6602498 (2003-08-01), Shen
patent: 2002/0064520 (2002-05-01), Rozenberg et al.
patent: 2003/0191098 (2003-10-01), D'Amato
patent: 2004/0254197 (2004-12-01), Tasaka et al.
patent: 0 657 463 (1995-06-01), None
patent: 4-221322 (1992-08-01), None
patent: 6-508369 (1994-09-01), None
patent: 8-117586 (1996-05-01), None
patent: 93/00076 (1993-01-01), None
patent: WO 93/24476 (1993-12-01), None
patent: WO 97/19694 (1997-06-01), None
patent: WO 99/39732 (1999-08-01), None
patent: WO 99/48535 (1999-09-01), None
patent: WO 00/07629 (2000-02-01), None
patent: WO 00/35422 (2000-06-01), None
patent: WO 00/45835 (2000-08-01), None
patent: WO 00/64483 (2000-11-01), None
patent: WO 01/51003 (2001-07-01), None
patent: WO 01/74400 (2001-10-01), None
patent: 03/053452 (2003-07-01), None
S.M. Foroutan et al., “The in vitro evaluation of polyethylene glycol esters of hydrocortisone 21-succinate as ocular prodrugs,”Intl. Journal of Pharma., vol. 182, pp. 79 to 92 (1999).
M.E. Szabo et al., “Ischemia and Reperfusion-Induced Histologic Changes in the Rat Retina,”Invest. Ophthal. &Visual Sci., vol. 32, No. 5, pp. 1471 to 1478 (1991).
Daniel W. Drolet et al., “Pharmacokinetics and Safety of an Anti-Vascular Endothelial Growth Factor Aptamer (NX1838) Following Injection into the Vitreous Humor of Rhesus Monkeys,”Pharmaceutical Research, vol. 17, No. 12, (2000), pp. 1503-1510.
The Eyetech Study Group, “Preclinical and Phase 1A Clinical Evaluation of an Anti-VEGF Pegylated Aptamer (Eye001) for the Treatment of Exudative Age-Related Macular Degeneration,”Retina, vol. 22, No. 2, (2002), pp. 143-151.
Sorbera et al., “Pegaptanib Sodium: Treatment of Age-Related Macular Degeneration Treatment of Diabetic Retinopathy Anti-VEGF Aptamer,”Drugs of the Future, vol. 27, No. 9, (2002), pp. 841-845.
Kuwano Mitsuaki
Nakagawa Masaki
Suhara Hiroshi
Frishauf Holtz Goodman & Chick P.C.
Kishore Gollamudi
Santen Pharmaceutical Co. Ltd.
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