Deletion muteins of hst-1

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.

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Details

435 691, 435 694, C07K 14475, C07K 14495

Patent

active

056398620

ABSTRACT:
A deletion type mutein of heparin-binding secretory transforming factor (hst-1) possesses excellent cell growth promoting activity and is stable. The present mutein can therefore be used as a therapeutic medicine such as a healing promoter for burns, wounds, surgical injuries etc.

REFERENCES:
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M. Taira et al., Proc. Nat'l. Acad. Sci. USA, 84:2980-2984 (1987).
T. Yoshida et al., Proc. Nat'l. Acad. Sci. USA, 84:7305-7309 (1987).
M. Toshida et al., Proc. Nat'l. Acad. Sci. USA, 85:4861-4864 (1988).
P. Bovi et al., Cell 50:729-737 (1987).
K. Miyagawa et al., Oncogene, 3:383-389 (1988).
P. Bovi et al., Molecular and Cellular Biology, 8:2933-2941 (1988).
W.E. Holmes et al., Biotechnology, 3:923-929 (1985).
K.A. Thomas, FASEB Journal, 1:6, pp. 434-440 (1987).

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