Deletion mutant of basic fibroblast growth factor and production

Details Deletion mutant of basic fibroblast growth factor and production Deletion mutant of basic fibroblast growth factor and production

1993-06-02

1994-10-04

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530399, 43525233, C12N 1500, C12N 120, C12P 2100, A61K 3736

Patent

active

053525892

ABSTRACT:
The present invention relates to the production, by recombinant DNA techniques, of derivatives of basic fibroblast growth factor (bFGF). These derivatives of bFGF can act as antagonists and/or superagonists of the wild type molecule in the angiogenic process. These derivatives, as well as wild type bFGF, may be prepared by the use of strains or E. coli which have been transformed with plasmids carrying nucleotide sequence coding for human and bovine bFGF and their derivatives.

REFERENCES:
patent: 4994559 (1991-02-01), Mascatelli et al.
patent: 5026839 (1991-06-01), Mascatelli et al.
Nagai, K. et al., Nature, 309: 810-812, 1984.
Dialog Information Services, File 154, Medline 82-89, Dialog accession No. 88162887, Seno M. et al.: "Stabilizing fibroblast growth factor using protein engineering", Biochem Res Commun Mar. 15, 1988, 151 (2) pp. 701-708.
Dialog Information Services File 55, Biosis, Biosis No. 87037476, Fox G. M. et al.: "Production biological activity and structure of recombinant basic fibroblast growth factor and an analog with cysteine replaced by serine", J. Biol Chem. 263 (34) 1988, 18452-18453.

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