Deletion mutant of a herpesvirus and vaccine containing said vir

Details Deletion mutant of a herpesvirus and vaccine containing said vir Deletion mutant of a herpesvirus and vaccine containing said vir

1988-08-02

1991-12-17

Warren, Charles F.

Drug, bio-affecting and body treating compositions

Lymphokine

4351723, 435236, 4351721, A61K 3912, C12N 1500, C12N 704

Patent

active

RE0337722

ABSTRACT:
The invention relates to live deletion mutants of a herpesvirus, especially of Pseudorabies virus. The genomes of the mutants differ from the genomes of the parent strain by the presence of one or more deletions selected from a deletion in the inverted repeats, a deletion in the unique sequence, and a deletion in the thymidine kinase gene.
The new deletion mutants are avirulent, do not induce latent infections, are stable and possess good immunogenic properties.
The invention also relates to vaccines containing the new mutant strains.

REFERENCES:
patent: 4322404 (1982-03-01), Gauri et al.
Gielkens et al., Current Topics in Veterinary Medicine and Chemical Science, vol. 17, pp. 3-13 (1982).
Virology, 127, 194-204, (1983), "Localization of the Regions of Homology between the Genomes of Herpes Simplex Virus, Type 1, and Psuedorabies Virus", Tamar Ben-Porat, Ruth Ann Veach, and Seiji Ihara.
Tenser, Richard B., et al.: "The Role of Pseudorabies Virus Thymidine Kinase Expression in Trigeminal Ganglion Infection", J. Gen. Virol., 64, (1983), pp. 1369-1373.
Paul, P. S. et al.: "Differentiation of Pseudorabies (Aujesky's Disease) Virus Strains by Restriction Endonuclease Analysis", Archives of Virology, 73, (1982), pp. 193-198.
Ihara, Seiji, et al.: "Comparison of the Physical and Genetic Maps of Pseudorabies Virus Shows That the Genetic Map is Circular", Virology, 122, (1982), pp. 268-278.
Rixon, Frazer J., Jr., et al.: "Structural Evolution of the DNA of Pseudorabies-Defective Viral Particles", Virology, 97, (1979), pp. 151-163.
Graham, F. L., et al.: "A New Technique for the Assay of Infectivity of Human Adenovirus 5 DNA", Virology, 52, (1973), pp. 456-467.
Platt, K. B., et al.: "Differentiation of Vaccine Strains and Field Isolates of Pseudorabies (Aujeszky's Disease) Virus: Trypsin Sensitivity and Mouse Virulence Markers", Archives of Virology, 63, (1980), pp. 107-114.
de Leeuw, P. W., et al.: "Intranasal Vaccination of Pigs Against Aujeszky's Disease 1. Comparison of Intranasal and Parenteral Vaccination with an Attenuated Vaccine in 12-Week-Old Pigs from Immunized Dams", The Veterinary Quarterly, 4, No. 2, (1982), pp. 49-56.

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