Deletion and glycosylation mutant of human tissue plasminogen ac

Details Deletion and glycosylation mutant of human tissue plasminogen ac Deletion and glycosylation mutant of human tissue plasminogen ac

1991-12-10

1993-11-02

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, 435219, C12N 964

Patent

active

052582981

ABSTRACT:
Thrombolytic proteins are disclosed which have tissue plasminogen-type activity. The proteins are characterized by modification within the 94 amino acid N-terminus, and/or at Arg-275, and/or at one or more of the N-linked glycosylation sites. Methods for making these proteins are disclosed as are therapeutic compositions containing same.

REFERENCES:
patent: 4766075 (1988-08-01), Goeddel
patent: 4853330 (1989-08-01), Goeddel
patent: 5002887 (1991-03-01), Larsen et al.
Pennica, D. et al., Nature, vol. 301 pp. 214-221, 1983.
Kagitani et al., Febs Letter, vol. 189, pp. 145-149, Sep. 1985.
Ny, J. et al., Proc. Natl. Acad. Sci, vol. 81, pp. 5355-5359, 1984.
Smith, G. et al., Molec. & Cell Biol., vol. 3, pp. 2156-2165, 1983.
van Zonneveld et al., J. Cell Biochemistry, vol. 32 pp. 169-178, 1986.
Klausner A. Biotechnology, vol. 4, pp. 706-711, Aug. 1986.
Berman, P. et al., Trends in Biotechnology, vol. 5, pp. 51-53, Feb. 1985.
Opdenakker et al., EMBO Workshop on Blasminogen Activators, Amalfi, Italy, Oct., 1985 "The Carbohydrate Side Chains of TPA Influence at Activity".
van Zonneveld et al., International Congress for the Society on Thrombosis and Hameostasis, Abstract 022 as evident of presentation, Jul. 15, 1985.
van Zonneveld et al., Proc. Natl. Acad. Sci. (PNAS), vol. 83, pp. 4670-4674, Jul. 1986.
Vehar et al., Cold Spring Harbor Symp. Quant Biol, vol. LI:551-62, 1986.
Verheijen et al, 1986, EMBO J 5:3525-3530.
Rijken et al., Biochem J 238:643-646, 1986.
Little et al., Biochem 23:6191-6195, 1986.
Harris et al., Mol Biol Med 3:279-292, 1984.
Tate et al., Biochem 26:338-343, 1987.
Kaufman et al., Mol Cell Biol. 5(7):1750-1759, 1985.
Banyai et al., FEBS 163:37-41, 1983.
Pohl, G. et al., Biochemistry, 23:3701-3707, 1984.
Zoller, M. et al., Nuc. Acid Res. 10:6487-6500, 1982.

Affiliated with

Also associated with

Rating

Deletion and glycosylation mutant of human tissue plasminogen ac does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Deletion and glycosylation mutant of human tissue plasminogen ac, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Deletion and glycosylation mutant of human tissue plasminogen ac will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1757023