Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1991-11-12
1996-09-24
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 530324, 530325, 530326, A61K 3816
Patent
active
055590950
ABSTRACT:
A method and compositions for reducing neuronal damage related to an ischemic condition in a mammalian subject are described. The method includes administration of a voltage-gated calcium channel-blocking compound to the subject, 4-24 hours after the onset of the ischemic condition. Such a calcium channel blocking compound is effective to block norepinephrine release in mammalian CNS neuronal cells and is characterized by specific, high affinity binding to omega-conotoxin MVIIA binding sites. Also disclosed are novel peptide structures useful in the treatment method of the invention.
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Bitner Robert S.
Bowersox Stephen S.
Fox James A.
Miljanich George P.
Valentino Karen L.
Dehlinger Peter J.
Lukton David
Neurex Corporation
Schain Howard E.
Stratford Carol A.
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