Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1994-12-12
1995-12-26
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424489, A61K 936
Patent
active
054785731
ABSTRACT:
A delayed, sustained-release pharmaceutical preparation is provided in which a water-soluble drug core is surrounded by a hydratable diffusion barrier which delays drug release for about 2-10 hours. The hydratable diffusion barrier comprises a film-forming polymer such as an acrylic resin or ethyl cellulose or mixtures thereof and an additive which controls the rate of hydration and permeability of the hydratable diffusion barrier selected from the group consisting of fully esterified acrylic resins containing quaternary amine side chains, lubricants, anionic surfactants, plasticizers, inert water-soluble materials, and mixtures thereof. In the preferred sustained-release pharmaceutical preparation, the film-forming polymer is combined with the additive and coated onto core drug granules to produce a diffusion barrier surrounding the core drug and form microparticles which may then be admixed with an immediate release drug.
REFERENCES:
patent: 3155590 (1964-11-01), Miller et al.
patent: 3341416 (1967-09-01), Anderson et al.
patent: 3488418 (1970-01-01), Holliday et al.
patent: 3492397 (1970-01-01), Peters et al.
patent: 3531418 (1970-09-01), Fanger et al.
patent: 4205060 (1980-05-01), Monsimer et al.
patent: 4524060 (1985-06-01), Mughal et al.
patent: 4716041 (1987-12-01), Kjornaes et al.
patent: 4752470 (1988-06-01), Mehta
patent: 4772475 (1988-09-01), Fukui et al.
patent: 4892740 (1990-01-01), Takasima et al.
patent: 4900558 (1990-02-01), Barry et al.
patent: 4968509 (1990-11-01), Radebaugh et al.
patent: 4983401 (1991-01-01), Eichel et al.
patent: 5026559 (1991-06-01), Eichel et al.
patent: 5112621 (1992-05-01), Stevens et al.
patent: 5188836 (1993-02-01), Muhammed et al.
patent: 5202128 (1993-04-01), Morella et al.
patent: 5376384 (1994-12-01), Eichel et al.
Lehmann et al, "The Use of Aqueous Synthetic-polymer Dispersions for Coating Pharmaceutical Dosage Forms", Pharmaceutical Laboratory of Rohm GmbH, Darmstadt.
Ozturk et al, "Mechanism of Release from Pellets Coated with an Ethylcellulose-Based Film," J. of Controlled Release, vol. 14, No. 3, Dec. 1990.
Blazek David R.
Eichel, deceased Herman J.
Massmann Brent D.
Benston, Jr. William E.
Kinaform Technology, Inc.
Page Thurman K.
LandOfFree
Delayed, sustained-release propranolol pharmaceutical preparatio does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Delayed, sustained-release propranolol pharmaceutical preparatio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Delayed, sustained-release propranolol pharmaceutical preparatio will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1367395