Delayed, sustained-release diltiazem pharmaceutical preparation

Details Delayed, sustained-release diltiazem pharmaceutical preparation Delayed, sustained-release diltiazem pharmaceutical preparation

1994-12-12

1996-06-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424469, 424489, 424409, 424472, A61K 936

Patent

active

055297900

ABSTRACT:
A delayed, sustained-release pharmaceutical preparation is provided in which a water-soluble drug core is surrounded by a hydratable diffusion barrier which delays drug release for about 2-10 hours. The hydratable diffusion barrier comprises a film-forming polymer such as an acrylic resin, esterified acrylic resin, or ethyl cellulose or mixtures thereof and an additive which controls the rate of hydration and permeability of the hydratable diffusion barrier selected from the group consisting of lubricants, anionic surfactants, plasticizers, inert water-soluble materials, and mixtures thereof. In the preferred sustained-release pharmaceutical preparation, the film-forming polymer is combined with the additive and coated onto core drug granules to produce a diffusion barrier surrounding the core drug and form microparticles when the drug core is the preferred diltiazem hydrochloride, different coating thicknesses of the diffusion barrier are used to provide a long delay component and a short delay component.

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Ozturk et al,"Mechanism of Release from Pellets coated with an Ethylcelloulose-Base Film," J. of Controlled Release, vol. 14, No. 3, Dec. 1990.

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