Delayed release pharmaceutical composition containing...

Details Delayed release pharmaceutical composition containing... Delayed release pharmaceutical composition containing...

2004-11-29

2008-08-12

Monshipouri, Maryam (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C558S190000, C558S237000, C560S032000, C560S037000

Reexamination Certificate

active

07410965

ABSTRACT:
A delayed release pharmaceutical formulation containing 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol or a pharmaceutically acceptable salt thereof in a matrix; said matrix containing from 1 to 80 wt. % of at least one pharmaceutically acceptable, matrix-forming, hydrophilic or hydrophobic polymer and having the following in vitro dissolution rate relative to 100 wt. % of the 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol contained in the formulation: 3-35 wt. % released after 0.5 hour, 5-50 wt. % released after 1 hour, 10-75 wt. % released after 2 hours, 15-82 wt. % released after 3 hours, 30-97 wt. % released after 6 hours, more than 50 wt. % released after 12 hours, more than 70 wt. % released after 18 hours, and more than 80 wt. % released after 24 hours.

REFERENCES:
patent: 4389393 (1983-06-01), Schor
patent: 4728513 (1988-03-01), Ventouras
patent: 6248737 (2001-06-01), Buschmann
patent: 3309516 (1983-12-01), None
patent: 3625458 (1987-02-01), None
patent: 0642788 (1995-03-01), None
patent: 0693475 (1996-01-01), None
patent: WO 02/43715 (2002-06-01), None
patent: WO 03/024444 (2003-03-01), None

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