Delayed drug-releasing microspheres

Details Delayed drug-releasing microspheres Delayed drug-releasing microspheres

1996-09-18

1999-11-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424468, 424457, A61K 914

Patent

active

059938552

ABSTRACT:
Microspheres prepared by emulsifying an aqueous phase containing a drug and an oil phase containing a biodegradable polymer to form a W/O emulsion, and then mixing and agitating this emulsion with another aqueous phase constituting a continuous phase to form a W/O/W emulsion. These microspheres can release a major portion of the drug after a predetermined period of time has elapsed after their administration to the patient, and are especially suitable for intracerebral implantation.

REFERENCES:
H.T. Wang et al., Journal of Controlled Release, 17(1), 23-32 (1991).
H.K. Sah et al., Journal of Microencapsulation, 12(1), 59-69 (1995).

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