Dehydroxyfluorination agent

Details Dehydroxyfluorination agent Dehydroxyfluorination agent

2007-06-25

2011-11-15

Choi, Ling (Department: 1761)

Organic compounds -- part of the class 532-570 series

Organic compounds

C252S182320, C570S123000, C570S124000, C570S126000

Reexamination Certificate

active

08058412

ABSTRACT:
There is provided a novel, useful dehydroxyfluorination agent containing sulfuryl fluoride (SO2F2) and an organic base that is free from a free hydroxyl group in the molecule. According to the present dehydroxyfluorination agent, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in large-scale use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, for example, 4-fluoroproline derivatives, 2′-deoxy-2′-fluorouridine derivatives, optically-active α-fluorocarboxylate derivatives, and monofluoromethyl derivatives, even in large scale.

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