Dehydrophenylahistins and analogs thereof and the synthesis...

Details Dehydrophenylahistins and analogs thereof and the synthesis... Dehydrophenylahistins and analogs thereof and the synthesis...

2006-06-20

2006-06-20

Wilson, James O. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C544S055000, C544S067000, C544S096000, C544S120000, C544S179000, C544S180000, C544S359000, C544S366000, C544S408000

Reexamination Certificate

active

07064201

ABSTRACT:
Compounds represented by the following structure (I) are disclosed:as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1′, R1″, R2, R3, R4, R5, and R6, X1and X2, Y, Z, Z1, Z2, Z3, and Z4may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.

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