Dehydrophenylahistins and analogs thereof and the synthesis...

Details Dehydrophenylahistins and analogs thereof and the synthesis... Dehydrophenylahistins and analogs thereof and the synthesis...

2011-06-07

2011-06-07

Moore, Susanna (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S254050, C544S370000, C544S366000

Reexamination Certificate

active

07956058

ABSTRACT:
Compounds represented by the following structure (I) are disclosed:as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1′, R1′, R2, R3, R4, R5, and R6, X1and X2, Y, Z, Z1, Z2, Z3, and Z4may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.

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