Dehydrooligopeptides, their production and their medicinal use

Details Dehydrooligopeptides, their production and their medicinal use Dehydrooligopeptides, their production and their medicinal use

1979-10-09

1981-06-30

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352

Patent

active

042762880

ABSTRACT:
New dehydrooligopepetides which bear, as one terminal substituent, an optionally substituted alkyl or alkenyl, optionally substituted aryl, optionally substituted heterocyclic radical, optionally substituted aralkyl or aralkenyl or a carbamoyl group and as the other terminal substituent a hydroxyl or amino, an optionally substituted alkylamino, optionally substituted arylamino, optionally substituted aralkylamino, an optionally substituted nitrogen-containing heterocyclic radical with five or six ring members optionally containing a further heteroatom, optionally substituted aralkoxy, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkylthio group or optionally substituted hydrazine demonstrate histolytic and tumor-resolving activity. The compounds are prepared by either hydrolyzing or aminolyzing the corresponding 2,4-disubstituted 5(4H)-oxazolones.

REFERENCES:
Rich, et al., J.C.S. (1974) 897-898.
Riordan, et al., Tetrahedron Letter, No. 16, (1976), 1247-1250.
Bodansky, et al., Chem. Abstr. 72, (1970) 83007t.
Weiner, et al., J.A.C.S. 88, (1966) 3851-3859.
Doherty, et al., J. Biol. Chem. 147, (1943).
Benoitan, et al., J. Chem. Soc. (1964) 824-836.
Patchornik, et al., J.A.C.S. 86, 1860-1861.

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