Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Chemical aftertreatment – e.g. – acylation – methylation – etc.
Patent
1998-10-30
2000-11-28
MacMillan, Keith
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Chemical aftertreatment, e.g., acylation, methylation, etc.
530344, 530857, C07K 114
Patent
active
061537314
ABSTRACT:
Dehydrodidemnin B with useful biological activity has formula (1). It can be isolated from natural sources or synthesized, and it forms active derivatives. ##STR1##
REFERENCES:
patent: 4493796 (1985-01-01), Rinehart, Jr.
Rinehart et al, J. Am. Chem. Soc., vol. 109, pp. 6846-6848 (1987).
K. L. Rinehart, Jr., J. Am. Chem. Soc. vol. 103, pp. 1857-1859, (1981).
Montgomery, D. W., Zukoski, C. F., Trasnplantation, vol. 40, pp. 49-56 (1985).
Montgomery et al., Fed. Prac., vol. 44, p. 634 (1987).
Rinehart, Jr. et al., Pure and Appl. Chem., vol. 54, pp. 2409-2424 (1982).
Rinehart, ESCOM, "Didemnin and Its Biological Properties", pp. 626-631, (1987).
Lithgow-Bertelloni Anna M.
Rinehart Kenneth L.
Linek Ernest V.
MacMillan Keith
Pharma Mar S.A.
Wessendorf T. D.
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