Dehydroalanine derivatives for protecting the skin, the mucous m

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice

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424701, 424450, 514844, 514845, 514846, 514944, 560169, 562444, 562449, 562569, A61K 748

Patent

active

058717552

ABSTRACT:
The present invention relates to the use of dehydroalanine derivatives of formula (I) ##STR1## with R.sub.1 : H or linear- or branched-chain C.sub.1 C.sub.4 alkyl, ##STR2## or linear- or branched-chain C.sub.1 -C.sub.20 alkyl where X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5 =H, halogen, hydroxyl, linear-or branched-chain C.sub.1 -C.sub.4 alkyl or alkoxy, ##STR3## and n=2, 3 or 4, for protecting the skin, the mucous membranes and/or the hair against oxidative stress and to the cosmetic and dermatological compositions containing such compounds and to new dehydroalanine derivatives.

REFERENCES:
Buc-Calderon et al, "Inhibition of 02.-AND HO. -mediated processes by a new class of free radical scavengers; the N-acyldehydroalanines", Free Rad. Res. Comms., vol. 5, No. 3, 1988, pp.159-168.
Brandt et al, "Synthesis of Bis and Tris (dehydroalanine) Crosslinking Agents and Their Use in the Preparation of Hydrophilic Nucleic Acid Base Resins", Journal of Polymer Science: Part C: Polymer Letters, vol. 24, 1986, pp. 199-206.
Stella et al, "Stabilization of Radicals by `Capto-Dative` Substitution -C-C Additoin to Radicophilic Olefins", Angew. Chem. Int. Ed. Engl., 17 (1978) No. 9, p. 691.

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