Dehydroabietylammonium salts of 6-oxo-2-piperidinecarboxylic aci

Details Dehydroabietylammonium salts of 6-oxo-2-piperidinecarboxylic aci Dehydroabietylammonium salts of 6-oxo-2-piperidinecarboxylic aci

1979-10-15

1981-03-03

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546243, C07D21178

Patent

active

042542618

ABSTRACT:
6-Oxo-2-piperidinecarboxylic acid has been resolved via direct crystallization of pure S-6-oxo-2-piperidinecarboxylic acid dehydroabietylammonium salt from a solvent system consisting of dimethylformamide, cyclohexane and acetone. The S-enantiomer is a required component for making certain tripeptides related to thyrotropin releasing hormone (TRH) which are central nervous system stimulants.

REFERENCES:
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patent: 4161600 (1979-07-01), Miller
Greenstein, J., et al., J. Am. Chem. Soc., 75, 1994 (1953).
Chemical Abstracts, 62: 591C (1965) [Sjoeberg, B., et al., Arkiv Kemi, 22 (32), 447-50 (1964)].
Gottstein, W., et al., J. Org. Chem., 30, 2072-3 (1965).
Kittila, R., Dimethylformamide Chemical Uses, E. I. Du Pont, Wilmington, 1967, pp. VIII-IX.

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