Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT),...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07105637

ABSTRACT:
The invention provides isolated dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), and methods of their synthesis. These compounds are useful in diagnosis of Smith-Lemli-Optiz syndrome (SLOS).

REFERENCES:
patent: WO 01/92893 (2001-12-01), None
Dehydro-oestriol and dehydropregnanetriol are candidate analytes for prenatal diagnosis of Smith-Lemli-Opitz syndrom. Prenat Diagn. Mar. 2001;21(3):207-12/ (In IDS of Jul. 2003).
Midgestational maternal urine steroid markers of fetal Smith-Lemli-Opitz (SLO) syndrome (7-dehydrocholesterol 7-reductase deficiency). Steroids. Jul. 1999;64(7):446-52. (In IDS of Jul. 2003).
Shackleton et al. Equine type estrogens produced by a pregnant woman carrying a Smith-Lemli-Opitz syndrome fetus J Clin Endocrinol Metab. Mar. 1999;84(3):1157-9 (In IDS of Jul. 2003).
Shackleton et al. Midgestational maternal urine steroid markers of fetal Smith-Lemli-Opitz (SLO) syndrome (7-dehydrocholesterol 7-reductase deficiency). Steroids. Jul. 1999;64(7):446-52. (In IDS of Jul. 2003).
Abuelo, et al., “Prenatal detection of the cholesterol biosynthetic defect in the Smith-Lemli-Opitz syndrome by the analysis of amniotic fluid sterols”,Am J Med Genet, (1995) vol. 56: 281-285.
Andersson, et al., “Adrenal insufficiency In Smith-Lemli-Opitz Syndrome”,Am. J. Med Genet, (1999) vol. 82 (5): 382-384.
Bradley, et al. “Levels of unconjugated estriol and other maternal serum markers in pregnancies with Smith-Lemli-Opitz (RSH) syndrome fetuses”,Am J Med Genet, (1999) vol. 82:355-358.
Clayton. “Disorders of cholesterol biosynthesis”,Arch. Dis. Child, (1998) vol. 78: 185-189.
Dallaire, et al. “Prenatal diagnosis of Smith-Lemli-Opitz syndrome is possible by measurement of 7-dehydrocholesterol in amniotic fluid”,Prenat. Diagn., (1995) vol. 15: 855-858.
Donnai, et al. “The lethal multiple congenital anomaly syndrome of polydactyly, sex reversal, renal hypoplasia, and unilobular lungs”,J. Med. Genet. (1986) vol. 23: 64-71.
Fitzky, et al. “Mutations in the delta-7-sterol reductase gene in patients with the Smith-Lemli-Opitz syndrome”,Proc. Natl. Acad. Sci. USA(1998) vol. 95: 8181-8186.
Glass, et al. “Steroid sulphatase deficiency is the major cause of extremely low oestriol production at mid-pregnancy: A urinary steroid assay for the discrimination of steroid sulphatase deficiency from other causes”,Prenat. Diagn., (1998) vol. 18: 789-800.
Li-Wei Guo, et al. “Synthesis of Ring B Unsaturated Estriols. Confirming the Structure of a Diagnostic Analyte for Smith -Lemil-Opitz Syndrome,” (2001) Organic Letters, vol. 3, No. 16, pp. 2547-2550.
Irons, et al., “Defective cholesterol biosynthesis in Smith-Lemli-Opitz syndrome”,Lancet, (1993) vol. 341:141.
Irons, et al. “Prenatal diagnosis of Smith-Lemli-Opitz syndrome”,Prenat. Diagn., (1998) vol. 18: 369-372.
Kelley. “Inborn errors of cholesterol biosynthesis”,Adv. Pediat., (2000) vol. 47: 1-53.
Kratz, et al. “Prenatal diagnosis of the RSH/Smith-Lemli-Opitaz syndrom”, Am. J. Med. Genet. vol. 82: 376-381 (1999).
McGaughran, et al. “Prenatal diagnosis of Smith-Lemli-Opitz syndrome”,Am. J. Med. Genet., (1995) vol. 56: 269-271.
McKeever, et al. “Smith-Lemli-Opitz syndrome II: A disorder of the fetal adrenals?”,J. Med. Genet., (1990) vol. 27: 465-466.
Mills, et al. “First trimester prenatal diagnosis of Smith-Lemli-Opitz syndrome (7-dehydrochloesterol) reductase deficiency”,Pediatr. Res., (1996) vol. 39: 816-819.
Moebius, et al. “Molecular cloning and expression of the human delta 7-sterol reductase”,Proc. Natl. Acad. Sci. USA, (1998) vol. 95: 1899-1902.
Palomaki, et al. “Maternal serum screening for Down syndrome in the United States: A 1995 survey”,Am. J. Med. Genet., (1997) vol. 176: 1046-1051.
Rossiter, et al. “Smith-Lemli-Opitz Syndrome: Prenatal diagnosis by quantification of cholesterol precursors in amniotic fluid”,American Journal of Medical Genetics, (1995) vol. 56: 272-275.
Shackleton. “Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research”,J. Steriod Biochem. Molec. Biol., (1993) vol. 45: 127-140.
Shackleton, et al. “Equine type estrogens produced by a pregnant woman carrying a Smith-Lemli-Opitz syndrome fetus”,J. Clin. Endrocrinol. Metab., (1999) vol. 84: 1157-1159.
Shackleton, et al. “Midgestational maternal urine steriod markers of fetal Smith-Lemli-Opitz syndrome (7-dehydrocholesterol 7-reductase deficiency)”,Steroids, (1999) vol. 64 446-452.
Shackleton, et al. “Neonatal urinary steroids in Smith-Lemi-Opitz Syndrome associated with 7-dehydrocholesterol reductase deficiency”,Steroids, (1999) vol. 64:481-490.
Shackleton, et al. “Dehydro-oestriol and dehydropregnanetroil are candidate analytes for prenatal diagnosis of Smith-Lemli-Opitz syndrome”,Prenat. Diagn., (2001) vol. 21: 207-212.
Sharp, et al. “First-trimester diagnosis of Smith-Lemli-Opitz syndrome”,Prenat. Diagn., (1997) vol. 17(4): 355-361.
Smith, et al. “A newly recognized syndrome of congenital nomalies”,J. Pediat., (1964) vol. 64: 210-221.
Steiner, et al. “Smith-Lemli-Opitz syndrome”,eMedicine J., (Apr. 4, 2001) vol. 2(4).
Steiner, et al. “Smith-Lemli-Opitz syndrome”,eMedicine J., (Feb. 5, 2002) vol. 3(2).
Tint, et al. “Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome”,N. Engl. J. Med., (1994) vol. 330: 107-113.
Tint, et al. “Fetal Smith-Lemli-Opitz syndrome can be detected accuratley and reliably by measuring amniotic fluid dehydrocholesterols”,Prenat. Diagn., (1998) vol. 18: 651-658.
Wassif et al., “Mutations in the human SterolΔ7-Reductase Gene at 11q12-13 Cause Smith-Lemli-Opitz Syndrome,”, Am. J. Hum. Genet. 63:55-62, 1998.
Waterham, et al. “Smith-Lemli-Opitz Syndrome is Cuased by Mutations in the 7-Dehydrocholesterol Reducatase Gene”,Am. J. Hum. Genet., (1998) vol. 63: 329-338.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT),... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT),..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT),... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3598426

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.