Dehydration/rehydration of derivatized, marker-loaded...

Details Dehydration/rehydration of derivatized, marker-loaded... Dehydration/rehydration of derivatized, marker-loaded...

2008-05-28

2010-12-28

Nguyen, Bao-Thuy L (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

C436S518000, C436S514000, C436S532000, C436S829000, C422S051000, C422S051000, C422S051000, C422S067000

Reexamination Certificate

active

07858397

ABSTRACT:
The present invention relates to a method for making a test device for detecting or quantifying an analyte in a sample. This method involves contacting a membrane with a mixture including derivatized, marker-loaded liposomes, and substantially dehydrating the mixture on the membrane under vacuum pressure at a temperature of from about 4° C. to about 80° C., wherein said mixture further includes one or more sugars in an amount sufficient to promote the stability of the liposomes during dehydration and rehydration. The present invention also relates to a test device and method for detecting or quantifying an analyte in a sample. The test device includes a membrane which includes an immobilized liposome zone, wherein the immobilized liposome zone has bound thereto dehydrated, derivatized, marker-loaded liposomes dehydrated under vacuum pressure at a temperature of from about 4° C. to about 80° C. from a mixture which includes one or more sugars in an amount sufficient to promote the stability of the liposomes during dehydration and rehydration.

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