Degradation-resistant fibrinogen sealants

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C514S013600, C514S014700, C424S094640, C435S214000

Reexamination Certificate

active

07968682

ABSTRACT:
Provided are degradation-resistant fibrinogen sealants comprising a first composition comprising one or more of fibrinogen γA/γ′ heterodimers and/or fibrinogen γ′/γ′ homodimers and a second composition comprising thrombin and, optionally, degradation-resistant fibrinogen sealants disclosed herein may further comprise Factor XIII and calcium. Degradation-resistant fibrinogen sealants are suitable for the treatment of trauma, particularly vascular trauma.

REFERENCES:
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