Degradation of epothilones

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C548S110000

Reexamination Certificate

active

10468919

ABSTRACT:
According to one embodiment the invention concerns a process for a degradation of an epothilone C or a epothilone D, wherein an epothilone C or epothilone D is subjected to an olefin metathesis in the presence of ethylene and subsequently an optional ester hydrolysis.

REFERENCES:
patent: 5969145 (1999-10-01), Schinzer et al.
patent: 6043372 (2000-03-01), Schinzer et al.
patent: 6156905 (2000-12-01), Schinzer et al.
patent: 6211412 (2001-04-01), Georg et al.
patent: 6288237 (2001-09-01), Hoefle et al.
patent: 6359140 (2002-03-01), Hofle et al.
patent: 6365749 (2002-04-01), Kim et al.
patent: 6380394 (2002-04-01), Nicolaou et al.
patent: 6441186 (2002-08-01), Nicolaou et al.
patent: 6498257 (2002-12-01), Vite et al.
patent: 6518421 (2003-02-01), Li et al.
patent: 6593115 (2003-07-01), Vite et al.
patent: 6605599 (2003-08-01), Vite et al.
patent: 2005/0090535 (2005-04-01), Reichenbach et al.
patent: 0 057 736 (1982-08-01), None
patent: WO 98/22461 (1998-05-01), None
Nicolaou et al., “Chemical Biology of Epothilones”, Angew. Chem. Int. Ed. 1998, vol. 37, No. 15, pp. 2014-2045.
March, J., “Advanced Organic Chemistry, Reactions, Mechanisms, and Structure”, New York, John Wiley & Sons, XP002200250, pp. 1146-1149.
Zhen Yang et al., “Die Totalsynthese von Epothilon A: der Zugang durch Olefinmetathese”, Angew. Chem. 1997, vol. 109, No. 1/2, pp. 170-172, XP-002095722.
Smith, A. et al., “Total Synthesis of (−)-Macrolactin A”, J. Am. Chem. Soc., 1996, vol. 118, pp. 13095-13096.
U.S. Appl. Ser. No. 09/313,524, filed May 17, 1999, Hoefle et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Degradation of epothilones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Degradation of epothilones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Degradation of epothilones will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3771756

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.