Degradable macromolecular magnetic resonance imaging...

Details Degradable macromolecular magnetic resonance imaging... Degradable macromolecular magnetic resonance imaging...

2005-08-15

2010-06-29

Jones, D L (Department: 1618)

Organic compounds -- part of the class 532-570 series

Organic compounds

Rare earth containing

C424S001110, C424S001650, C424S009300, C424S009340, C424S009350, C424S009360, C424S009362, C424S009363

Reexamination Certificate

active

07745590

ABSTRACT:
Degradable macromolecular magnetic resonance imaging contrast agents for use in various diagnostic procedures, and methods for synthesizing, using and degrading these agents, are described. The macromolecule contrast agents disclosed in various aspects of this invention are degradable gadolinium compounds which show prolonged plasma retention, and enhanced permeability and retention in solid tumors, but are still capable of being rapidly cleared from the body.

REFERENCES:
patent: 6982324 (2006-01-01), Lu et al.
Silvia Arpicco et al.,Bioconjugate Chem.,vol. 8, No. 3, pp. 327-337 (1997), “New Coupling Reagents for the Preparation of Disulfide Cross-Linked Conjugates with Increased Stability.”
Zheng-Rong Lu et al.,Magnetic Resonance in Medicine,vol. 51, pp. 27-34 (2004), “Extracellular Biodegradable Macromolecular Gadolinium (III) Complexes for MRI.”
Aaron M. Mohs et al.,Bioconjugate Chem.,vol. 15, No. 6, pp. 1424-1430 (2004), “PEG-g-poly (GdDTPA-co-L-cystine): A Biodegradable Macromolecular Blood Pool Contrast Agent for MR Imaging.”
Yuda Zong et al.,Magnetic Resonance in Medicine,vol. 53, pp. 835-842 (2005), “Contrast-Enhanced MRI With New Biodegradable Macromolecular Gd(III) Complexes in Tumor-Bearing Mice.”

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