Degradable macromolecular magnetic resonance imaging...

Details Degradable macromolecular magnetic resonance imaging... Degradable macromolecular magnetic resonance imaging...

2006-01-03

2006-01-03

Jones, Dameron L. (Department: 1616)

Organic compounds -- part of the class 532-570 series

Organic compounds

Rare earth containing

C424S001110, C424S001650, C424S009360

Reexamination Certificate

active

06982324

ABSTRACT:
Novel degradable macromolecular magnetic resonance imaging contrast agents for use in various diagnostic procedures, and methods for synthesizing, using and degrading these agents, are disclosed. The macromolecule contrast agents disclosed in various aspects of this invention are degradable gadolinium compounds which show prolonged plasma retention, and enhanced permeability and retention in solid tumors, but are still capable of being rapidly cleared from the body.

REFERENCES:
Arpicco, Silvia; Dosio, Franco; Brusa, Paola; Crosasso, Paola, and Cattel, Luigi,Bioconjugate Chem.,vol. 8, No. 3, 1997, “New Coupling Reagents for the Preparation of Disulfide Cross-Linked Conjugates with Increased Stability”.

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