Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-01-02
2007-01-02
Harris, Alana M. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S380000, C514S001000, C514S002600, C514S008100, C514S012200, C424S094100, C424S094300, C424S094640, C436S064000, C436S086000
Reexamination Certificate
active
09502176
ABSTRACT:
Disclosed are deglycosylated fragments of a kringle 1-3 region of plasminogen, nucleotides encoding deglycosylated kringle 1-3 region proteins and antibodies specific for deglycosylated kringle 1-3 region proteins. The compositions of the present invention have increased antiangiogenic activity as compared to previously isolated kringle 1-3 region proteins. Also included in the present invention are methods of treating angiogenesis-associated diseases and conditions such as cancer using the compositions described herein.
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Amino acid database, Accession No. P00747, Jul. 21, 1986.
Sim, B. Kim Lee et al. A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer. Cancer research 57:1329-1334, Apr. 1, 1997.
Sequence alignment between Applicants' SEQ ID No.: 2 and U.S. 20030012792 A1, sequence No. 61, 2003.
Cao et al. Kringle structures and antiangiogenesis. Curr. Med. Chem.-Anti-Cancer Agents 2: 667-681, Aug. 2002.
Cao, Y. et al., Kringle Domains of Human Angiostatin,The Journal of Biological Chemistry, vol./Iss: 271 (46), pp. 29461-29467, Nov. 15, 1996.
Folkman M. Judah
LiAng Hong
MacDonald Nicholas
Pirie-Shepherd Steven
Sim Kim Lee
Harris Alana M.
Kilpatrick & Stockton LLP
The Children's Medical Center Corporation
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