Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1984-01-13
1986-09-30
Kight, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530830, 424101, 514 2, 514802, C07G 700, A61K 3516
Patent
active
046147950
ABSTRACT:
Highly purified, biologically active Human Factor VIII:C having specific activities of about 4000-8000 units per milligram of protein is prepared. In the method of preparation, an AHF concentrate is solubilized or equilibrated in an aqueous medium and treated to change the effective Stokes' radius of the Factor VIII:C to an apparently low value and then subjected to a separation from the concentrate. Treatment of the highly purified Factor VIII:C with a mixture of glycosidases causes substantial removal of carbohydrate side chains without reduction of procoagulant activity and with retention of significant in vivo survival time.
REFERENCES:
patent: 4188318 (1980-02-01), Shanbrom
patent: 4278594 (1981-07-01), Amrani
patent: 4361509 (1982-11-01), Zimmerman et al.
patent: 4383989 (1983-05-01), Rock
patent: 4495175 (1985-01-01), Chavin et al.
patent: 4508709 (1985-04-01), Amphlett et al.
Chavin Stephen I.
Fay Philip J.
Gibblin James
Hallenbeck Robert M.
Kight John
LuKacher Martin L.
Nutter Nathan M.
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