Deformylation of f-Met peptides in bacterial expression systems

Details Deformylation of f-Met peptides in bacterial expression systems Deformylation of f-Met peptides in bacterial expression systems

1997-07-17

1998-11-10

Ketter, James

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 694, 435228, 43525233, 4353201, C12P 2102

Patent

active

058342435

ABSTRACT:
A method for producing recombinant peptides and proteins having a diminished retention of N-formyl-methionine by coexpressing a peptide deformylase enzyme is disclosed. Also disclosed are substantially deformylated protein compositions and transformed bacterial cells and DNA vectors useful for acheiving such deformylation.

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