Defense and counter-defense compositions and methods

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

Reexamination Certificate

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C424S094610, C424S094600

Reexamination Certificate

active

07943127

ABSTRACT:
Contemplated compositions and methods are directed to the use of a proteinase to reduce capsaicin-induced pain sensation in a mammal. Preferably, the proteinase comprises a bromelain preparation in a liquid formulation for topical or enteral administration. In additional aspects of the inventive subject matter, a proteinase inhibitor is present in pepper spray to avoid inactivation of capsaicin by a proteinase.

REFERENCES:
patent: 4842873 (1989-06-01), Takenawa et al.
patent: 5395541 (1995-03-01), Carpenter et al.
Mueen Aslam et al. “Proteases in Milk” Ilini DairyNet University of Illinois Extension Aug. 5, 1998 2 pgs.
Leslie Ann Jones et al “Household Treatment for ”Chile Burns“ of the Hands” Clinical Toxicology, 25(6), 483-491 (1987).
The great hot sauce book Jennifer Trainer Thompson “The Great Hot Sauce Book” Published by Ten Speed Press, 1995 ISBN 0898157838, 9780898157833 2 pgs.
H.R. Maurer, “Bromelain: biochemestry, pharmacology and medical use” CMLS, Cell. Mol. Life Sci, 58 (2001) 1234-1245.

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