Chemistry: molecular biology and microbiology – Vector – per se
Patent
1998-10-05
2000-10-31
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Vector, per se
4241841, 4241871, 4241881, 4242041, 435147FOR, 435157FOR, 435180FOR, 435182FOR, 435190FOR, 536 231, 536 2372, C12N 1500
Patent
active
061401145
ABSTRACT:
The present invention relates to a vaccine consisting of defective viral particles as are obtained in vivo or ex vivo, in individuals infected or capable of being infected with a virus, after expression of the genes carried by a vector or a combination of vectors and comprising at least the structural genes necessary for the constitution of the viral particle.
REFERENCES:
Aids Research and Human Retroviruses, vol. 7, No. 12, Dec. 1991, pp. 991-998, XP000607853 Jenkins, S. et al.: "Formation of lentivirus particles by mammalian cells infected with recombinant fowlpox virus" see the whole document.
Virology, vol. 194, No. 1, May 1993, Orlando US, pp. 192-199, XP000608725 Dong, J. & Hunter E.: "Analysis of retroviral assembly using a Vaccinia/T7-polymerase complemenation system" see the whole document.
Gene Therapy, vol. 2, No. Suppl. 01, Nov. 17, 1995, p. S12XP000617926 Savard N Et Al.: "Transient Retroviral Packaging Systems Generated By Herpes Simplex Virus Derived Vectors" see abstract.
Vaccine, vol. 13, No. 11, Aug. 1995, pp. 1013-1022, XP000571592 Moldoveanu Z Et Al: "Immune Responses Induced By Administration Of Encapsidated Poliovirus Replicons Which Express HIV-1 GAG And Envelope Proteins" see the whole document.
Nature, vol. 379, No. 6562, Jan. 18, 1996, London GB, pp. 273-277, XP000608484 Diaz, J.J. et al.: "Post-transcriptional transactivation of human retroviral envelope glycoprotein expression by herpes simplex virus Us11 protein" cited in the application see the whole document.
Hasegawa et al. "Retroviral Transfer of HSV1-TK Gene into Human Lung Cancer Cell Line", Journal of Molecular Medicine, vol. 73, No. 73, (Mar. 1995), pp. 107-112. (complete reference).
Klatzmann David
Salzmann Jean-Loup
Stucker Jeffrey
Universite Pierre Et Marie Curie (Paris VI)
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