Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1994-08-30
1996-12-10
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4353201, C12N 1586, C12N 510, C12N 1500, C12N 1563
Patent
active
055830226
ABSTRACT:
The invention relates to a defective recombinant retrovirus containing a sequence coding for a specific protein in the genome of the cells. The DNA of the recombinant retrovirus contains the sequence coding for the protein intercalated between an acceptor splicing site and a donor splicing site, the whole assembly being placed under the control of a suitable promoter under conditions such that the infection of the said cells by this recombinant retrovirus is accompanied by the incorporation of the sequence coding for the protein into the genome of the infected cells.
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Anderson et al. Chemical Abstracts, vol. 99, No. 1, pp. 163-164, 17374s (1983).
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J. R. McLachlin et al (1990) Prog. in Nucl. Acid Res. and Mol. Biol. 38:91-135.
T. Heidmann et al (1988) Proc. Natl. Acad Sci. USA 85:2219-2223.
Heidmann Thierry
Nicolas Jean-Fran.cedilla.ois
Fleisher Mindy
Institut National de la Sante et de la Recherche Medicale
Institut Pasteur
Railey II Johnny F.
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