Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1998-06-11
2000-02-22
Campell, Bruce R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
4353201, 435325, 435354, 435455, 435463, 536 231, 536 235, 800 21, 800 23, 800 25, C07H 2104, C12N 500, C12N 506, C12N 510, C12N 1500
Patent
active
060282444
ABSTRACT:
The invention provides a nonhuman transgenic animal having a transgene disrupting or interfering with expression of G.alpha..sub.q chromosomally integrated into the germ cells of the animal. Cells and cell lines derived from these nonhuman transgenic animals; a method for producing a transgenic nonhuman animal having a phenotype characterized by expression of a transgene which is otherwise not naturally occurring, where the expression of the transgene disrupts or interferes with G.alpha..sub.q activity; a method for determining an effect of an agent on G.alpha..sub.q expression, by administering an effective amount of the agent to a transgenic nonhuman animal having a transgene disrupting or interfering with G.alpha..sub.q, and measuring a physiological response of the transgenic nonhuman animal to the agent, and comparing the physiological response of the transgenic nonhuman animal having a transgene disrupting or interfering with G.alpha..sub.q to a control animal is also provided.
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Offermanns Stefan
Toombs Christopher F.
Baker Anne-Marie
California Institute of Technology
Campell Bruce R.
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